Selectins: A family of adhesion receptors

Selectins: a family of adhesion receptors.

Recent data have shown that a group of cell surface proteins, originally studied independently as lymphocyte homing receptors or as activation-induced surface proteins of platelets and/or endothelial cells (Stoolman, 1989) are structurally related. Each is an integral membrane protein with an N-terminal, C-type lectin domain followed by an EGF-like module, multiple copies of the consensus repea...

Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

Leukocyte adhesion: Two selectins converge on sulphate

The selectins are a family of cell–cell adhesion proteins that participate in leukocyte–endothelial and leukocyte– platelet interactions [1–4]. The family consists of three members: P-selectin, expressed on activated endothelium and platelets; E-selectin, expressed on activated endothelium; and L-selectin, expressed on circulating leukocytes (Fig. 1). During the process of leukocyte emigration ...

Adhesion family of G protein-coupled receptors and cancer.

The adhesion-class G protein-coupled receptors (adhesion-GPCRs) constitute the second largest GPCR sub-family in humans. Adhesion-GPCRs are defined by the chimeric structure of an unusually large extracellular cell-adhesion domain and a GPCR-like seven-pass transmembrane domain. Adhesion-GPCRs are hence expected to display both cellular adhesion and signaling functions in many biological system...

Selectins and their counter receptors: a bitter sweet attraction.

Selectins are adhesion receptors expressed by leucocytes, platelets, and endothelial cells. They mediate the initial binding of leucocytes to vascular endothelium in the post-capillary venules. This is an essential first step in leucocyte migration into tissue. The selectin family of adhesion receptors consists of three C-type lectins (E, P, and L selectin). Their ligands (counter structures) a...